The AI molecule company for cryopreservation

We design new cryoprotectants that protect tissue from ice at doses cells can survive.

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From computer model to transplantation

We screen candidate molecules on the computer first. Our cryobiology lab then tests the most promising ones for ice protection, glass formation and toxicity.

1Computational design

Machine learning models predict toxicity and glass-forming capacity from composition and then propose new candidates.

  1. 10⁵ to 10⁷candidates in the library
  2. 10³ to 10⁵after fast screening
  3. 500 to 1,000after the membrane toxicity filter
  4. 50 to 200confirmed by molecular dynamics
Planned number of candidates at each stage of our discovery process. This is design capacity, not results.

2High-throughput screening

We are building robotic screens and vision models to score glass formation in hundreds of variants every week.

0wells scored as glass

  • Glass
  • Haze
  • Ice
  • Empty
Illustration of a screening plate, not measured data.

3Organ-specific optimization

Every organ differs in its vessels, size and tolerance, so each one gets its own formulation.

Transplanted, the kidney keeps the recipient alive.

  1. The recipient has no working kidney.
  2. The donor kidney is vitrified and stored at −140 °C.
  3. It is rewarmed and starts to work again.
  4. Transplanted, the kidney keeps the recipient alive.
Illustration of our goal. Rats have lived on vitrified, rewarmed kidneys. In pigs, follow-up so far is two hours.

See our approach

The problem

27.9 %

of recovered deceased donor kidneys in the US were not transplanted in 2023.

A bag of cryoprotective agent solution with a blue label lying on a green drape inside a scanner, another bag behind it

Donor organs only last hours

When blood flow stops, tissue starts to run out of oxygen. This is called ischemia. Cold storage slows the damage, but it cannot stop it.

Read the science

Cryoprotectants damage cells at the doses that stop ice

Cryoprotective agents, or CPAs, keep ice from forming. To vitrify tissue, which means turning its water into glass instead of ice, you need so much CPA that it damages cells.

Try the CPA dose explorer

What has been shown

Results of the field so far. Vitrification is routine for embryos. In animals, whole organs have been vitrified, and some have been transplanted.

  1. Since 1985

    Embryos

    Embryos vitrified. Today this is routine in reproductive medicine.

    Routine

  2. 2009

    Rabbit kidney

    A vitrified kidney was transplanted. One animal survived, with impaired function.

    Peer reviewed

  3. 2023

    Rat kidneys

    Stored for up to 100 days. All five recipients survived on the transplanted kidney.

    Peer reviewed

  4. 2025

    Pig liver

    Vitrified at liter scale without ice or cracks. Viability was not tested.

    Peer reviewed

  5. 2026

    Pig kidneys

    Stored for over a year, rewarmed and transplanted. Follow-up lasted two hours.

    Preprint

  6. Goal

    Human organs

    A human organ vitrified, rewarmed and transplanted has not yet been shown. Organ banking is a research goal, not a current capability.

    Research goal

See the evidence